[HTML][HTML] Presynaptic N-methyl-d-aspartate (NMDA) receptor activity is increased through protein kinase C in paclitaxel-induced neuropathic pain
Painful peripheral neuropathy is a severe adverse effect of chemotherapeutic drugs such as
paclitaxel (Taxol). The glutamate N-methyl-d-aspartate receptors (NMDARs) are critically
involved in the synaptic plasticity associated with neuropathic pain. However, paclitaxel
treatment does not alter the postsynaptic NMDAR activity of spinal dorsal horn neurons. In
this study, we determined whether paclitaxel affects presynaptic NMDAR activity by
recording excitatory postsynaptic currents (EPSCs) of dorsal horn neurons in spinal cord …
paclitaxel (Taxol). The glutamate N-methyl-d-aspartate receptors (NMDARs) are critically
involved in the synaptic plasticity associated with neuropathic pain. However, paclitaxel
treatment does not alter the postsynaptic NMDAR activity of spinal dorsal horn neurons. In
this study, we determined whether paclitaxel affects presynaptic NMDAR activity by
recording excitatory postsynaptic currents (EPSCs) of dorsal horn neurons in spinal cord …