Role of co-repressors in transcriptional repression mediated by the t (8; 21), t (16; 21), t (12; 21), and inv (16) fusion proteins
SW Hiebert, B Lutterbach, J Amann - Current opinion in …, 2001 - journals.lww.com
SW Hiebert, B Lutterbach, J Amann
Current opinion in hematology, 2001•journals.lww.comAbstract The t (8; 21), t (16; 21), inv (16), and t (12; 21) are some of the most frequent
chromosomal translocations found in acute myeloid and acute lymphoblastic leukemia. The
fusion proteins created by these chromosomal translocations are transcriptional repressors.
A full understanding of the types of proteins that these fusion proteins recruit to repress
transcription will not only clarify understanding of the molecular mechanism of action of
these fusion proteins but also provide further targets for therapeutic intervention.
chromosomal translocations found in acute myeloid and acute lymphoblastic leukemia. The
fusion proteins created by these chromosomal translocations are transcriptional repressors.
A full understanding of the types of proteins that these fusion proteins recruit to repress
transcription will not only clarify understanding of the molecular mechanism of action of
these fusion proteins but also provide further targets for therapeutic intervention.
Abstract
The t (8; 21), t (16; 21), inv (16), and t (12; 21) are some of the most frequent chromosomal translocations found in acute myeloid and acute lymphoblastic leukemia. The fusion proteins created by these chromosomal translocations are transcriptional repressors. A full understanding of the types of proteins that these fusion proteins recruit to repress transcription will not only clarify understanding of the molecular mechanism of action of these fusion proteins but also provide further targets for therapeutic intervention.
Lippincott Williams & Wilkins