Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing
G Parruti, F Peracchia, M Sallese, G Ambrosini… - Journal of Biological …, 1993 - ASBMB
The cDNA for human beta-arrestin-1 was cloned by polymerase chain reaction (PCR) and
identified based on its remarkably high amino acid identity (98.6%) with the bovine
sequence. Two alternatively spliced isoforms of human beta-arrestin-1, differing only in the
presence or absence of 24 base pairs/8 amino acids within the sequence, were identified
and called beta-arrestin-1A and beta-arrestin-1B, respectively. Both isoforms were found in
all tissues tested. Southern blot analysis revealed the existence of a single gene for beta …
identified based on its remarkably high amino acid identity (98.6%) with the bovine
sequence. Two alternatively spliced isoforms of human beta-arrestin-1, differing only in the
presence or absence of 24 base pairs/8 amino acids within the sequence, were identified
and called beta-arrestin-1A and beta-arrestin-1B, respectively. Both isoforms were found in
all tissues tested. Southern blot analysis revealed the existence of a single gene for beta …
