[HTML][HTML] Transcriptional repression of the transforming growth factor β (TGF-β) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor …
C Liu, X Chen, L Yang, T Kisseleva, DA Brenner… - Journal of Biological …, 2014 - ASBMB
TLR4 signaling induces down-regulation of the bone morphogenic protein (BMP) and activin
membrane-bound inhibitor (BAMBI), which enhances TGF-β signaling during hepatic
stellate cell (HSC) activation. We investigated the mechanism by which TLR4 signaling
down-regulates BAMBI expression in HSCs and found that TLR4-and TNF-α-mediated
BAMBI down-regulation is dependent on regulation of BAMBI promoter activity through the
interaction with NF-κBp50 and HDAC1 in HSCs. Bambi was predominantly expressed in …
membrane-bound inhibitor (BAMBI), which enhances TGF-β signaling during hepatic
stellate cell (HSC) activation. We investigated the mechanism by which TLR4 signaling
down-regulates BAMBI expression in HSCs and found that TLR4-and TNF-α-mediated
BAMBI down-regulation is dependent on regulation of BAMBI promoter activity through the
interaction with NF-κBp50 and HDAC1 in HSCs. Bambi was predominantly expressed in …