Monotherapy of RAAS blockers and mobilization of aldosterone: A mechanistic perspective study in kidney disease

G Gupta, R Dahiya, Y Singh, A Mishra, A Verma… - Chemico-biological …, 2020 - Elsevier
In patients with acute kidney injury progressively converting into chronic kidney disease
(CKD), proteinuria and high blood pressure predict progression to end-stage renal disease
(ESRD). Although, Renin-angiotensin-aldosterone system (RAAS) regulates blood pressure
and kidney disease through both direct and indirect mechanisms. RAAS blockers that act at
the level of angiotensin or lower in the cascade can cause compensatory increases in the
plasma renin and angiotensin II level. Here, in this review article, we are exploring the …