p53 Stimulates Promoter Activity of the sgk Serum/Glucocorticoid-inducible Serine/Threonine Protein Kinase Gene in Rodent Mammary Epithelial Cells (∗)
AC Maiyar, AJ Huang, PT Phu, HH Cha… - Journal of Biological …, 1996 - ASBMB
sgk is a novel member of the serine/threonine protein kinase gene family that is
transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells. To
functionally determine if the sgk promoter is regulated by the p53 tumor suppressor protein
in mammary cells, a series of sgk promoter fragments with 5′-deletions were linked to the
bacterial chloramphenicol acetyltransferase gene (sgk-CAT) and transiently cotransfected
into nontumorigenic NMuMG or transformed Con8Hd6 mammary epithelial cells with p53 …
transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells. To
functionally determine if the sgk promoter is regulated by the p53 tumor suppressor protein
in mammary cells, a series of sgk promoter fragments with 5′-deletions were linked to the
bacterial chloramphenicol acetyltransferase gene (sgk-CAT) and transiently cotransfected
into nontumorigenic NMuMG or transformed Con8Hd6 mammary epithelial cells with p53 …
