Geriatric assessment–driven intervention (GAIN) on chemotherapy-related toxic effects in older adults with cancer: a randomized clinical trial

D Li, CL Sun, H Kim, E Soto-Perez-de-Celis… - JAMA …, 2021 - jamanetwork.com
Importance Although geriatric assessment–driven intervention improves patient-centered
outcomes, its influence on chemotherapy-related toxic effects remains unknown. Objective
To assess whether specific geriatric assessment–driven intervention (GAIN) can reduce
chemotherapy-related toxic effects in older adults with cancer. Design, Setting, and
Participants A randomized clinical trial enrolled 613 participants from a National Cancer
Institute–designated cancer center between 2015 and 2019. Patients were 65 years and …