P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production
E Schepers, N Meert, G Glorieux… - Nephrology Dialysis …, 2007 - academic.oup.com
E Schepers, N Meert, G Glorieux, J Goeman, J Van der Eycken, R Vanholder
Nephrology Dialysis Transplantation, 2007•academic.oup.comBackground. Chronic renal insufficiency is associated with the retention of solutes normally
excreted by healthy kidneys. P-cresol, a prototype protein-bound uraemic retention solute,
has been shown to exert toxic effects in vitro. Recently, however, it has been demonstrated
that p-cresol in the human body is conjugated, with p-cresylsulphate as the main metabolite.
Methods. The present study evaluates the effect of p-cresylsulphate on the respiratory burst
activity of leucocytes. Results. P-cresylsulphate significantly increased the percentage of …
excreted by healthy kidneys. P-cresol, a prototype protein-bound uraemic retention solute,
has been shown to exert toxic effects in vitro. Recently, however, it has been demonstrated
that p-cresol in the human body is conjugated, with p-cresylsulphate as the main metabolite.
Methods. The present study evaluates the effect of p-cresylsulphate on the respiratory burst
activity of leucocytes. Results. P-cresylsulphate significantly increased the percentage of …
Abstract
Background. Chronic renal insufficiency is associated with the retention of solutes normally excreted by healthy kidneys. P-cresol, a prototype protein-bound uraemic retention solute, has been shown to exert toxic effects in vitro. Recently, however, it has been demonstrated that p-cresol in the human body is conjugated, with p-cresylsulphate as the main metabolite.
Methods. The present study evaluates the effect of p-cresylsulphate on the respiratory burst activity of leucocytes.
Results. P-cresylsulphate significantly increased the percentage of leucocytes displaying oxidative burst activity at baseline. Oxidative burst activity of stimulated leucocytes was however not affected. In contrast, p-cresol had no effect on the leucocytes at baseline, but inhibited leucocytes burst activity after stimulation.
Conclusion. The present study demonstrates, for the first time, that p-cresylsulphate, the main in vivo metabolite of p-cresol, has a pro-inflammatory effect on unstimulated leucocytes. This effect could contribute to the propensity to vascular disease in the uraemic population.
Oxford University Press