[HTML][HTML] The splice of life: does RNA processing have a role in HIV-1 persistence?
AO Pasternak, B Berkhout - Viruses, 2021 - mdpi.com
AO Pasternak, B Berkhout
Viruses, 2021•mdpi.comAntiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus.
Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main
obstacle to achieving an HIV-1 cure. However, these HIV-1 reservoirs are not
transcriptionally silent, and viral transcripts can be detected in most ART-treated individuals.
HIV-1 latency is regulated at the transcriptional and at multiple post-transcriptional levels.
Here, we review recent insights into the possible contribution of viral RNA processing to the …
Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main
obstacle to achieving an HIV-1 cure. However, these HIV-1 reservoirs are not
transcriptionally silent, and viral transcripts can be detected in most ART-treated individuals.
HIV-1 latency is regulated at the transcriptional and at multiple post-transcriptional levels.
Here, we review recent insights into the possible contribution of viral RNA processing to the …
Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus. Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main obstacle to achieving an HIV-1 cure. However, these HIV-1 reservoirs are not transcriptionally silent, and viral transcripts can be detected in most ART-treated individuals. HIV-1 latency is regulated at the transcriptional and at multiple post-transcriptional levels. Here, we review recent insights into the possible contribution of viral RNA processing to the persistence of HIV-1 reservoirs, and discuss the clinical implications of persistence of viral RNA species in ART-treated individuals.
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