[HTML][HTML] Oxidative and nitrosative stress and histone deacetylase-2 activity in exacerbations of COPD
J Footitt, P Mallia, AL Durham, WE Ho… - Chest, 2016 - Elsevier
Background Respiratory virus infections are commonly associated with COPD
exacerbations, but little is known about the mechanisms linking virus infection to
exacerbations. Pathogenic mechanisms in stable COPD include oxidative and nitrosative
stress and reduced activity of histone deacetylase-2 (HDAC2), but their roles in COPD
exacerbations is unknown. We investigated oxidative and nitrosative stress (O&NS) and
HDAC2 in COPD exacerbations using experimental rhinovirus infection. Methods Nine …
exacerbations, but little is known about the mechanisms linking virus infection to
exacerbations. Pathogenic mechanisms in stable COPD include oxidative and nitrosative
stress and reduced activity of histone deacetylase-2 (HDAC2), but their roles in COPD
exacerbations is unknown. We investigated oxidative and nitrosative stress (O&NS) and
HDAC2 in COPD exacerbations using experimental rhinovirus infection. Methods Nine …
