How does the timing of antiretroviral therapy initiation in acute infection affect HIV reservoirs?
J Ananworanich, K Dubé… - Current Opinion in HIV and …, 2015 - journals.lww.com
It is clear that early ART has a greater impact in limiting the HIV reservoirs than later
treatment. However, latently infected long-lived memory CD4+ T cells persist in most early
treated individuals. Therefore, additional interventions will likely be required to eliminate all
cells capable of producing replication-competent virus but treatment in AHI may be the
critical first step in containing the HIV reservoirs.
treatment. However, latently infected long-lived memory CD4+ T cells persist in most early
treated individuals. Therefore, additional interventions will likely be required to eliminate all
cells capable of producing replication-competent virus but treatment in AHI may be the
critical first step in containing the HIV reservoirs.
Summary
It is clear that early ART has a greater impact in limiting the HIV reservoirs than later treatment. However, latently infected long-lived memory CD4+ T cells persist in most early treated individuals. Therefore, additional interventions will likely be required to eliminate all cells capable of producing replication-competent virus but treatment in AHI may be the critical first step in containing the HIV reservoirs.
Lippincott Williams & Wilkins