Effect of FK506 versus cyclosporine on human natural and antibody-dependent cytotoxicity reactions in vitro
M WAsIK, A Gorski, B STEPIEN-SOPNIEWSKA… - …, 1991 - journals.lww.com
M WAsIK, A Gorski, B STEPIEN-SOPNIEWSKA, Z Lagodzinski
Transplantation, 1991•journals.lww.comThe effect of FK506 and cyclosporine on NK and ADCC activity was evaluated. Cytotoxic
cells mediating both activities are resistant to FK506. In contrast, preincubation of ADCC and
NK effectors with cyclosporine decreases their cytotoxic potential, while adding the drug to
the assays is without effect.
cells mediating both activities are resistant to FK506. In contrast, preincubation of ADCC and
NK effectors with cyclosporine decreases their cytotoxic potential, while adding the drug to
the assays is without effect.
Abstract
The effect of FK506 and cyclosporine on NK and ADCC activity was evaluated. Cytotoxic cells mediating both activities are resistant to FK506. In contrast, preincubation of ADCC and NK effectors with cyclosporine decreases their cytotoxic potential, while adding the drug to the assays is without effect.
Lippincott Williams & Wilkins