Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection
Journal of virology, 2007•Am Soc Microbiol
The relationship between the function of human immunodeficiency virus (HIV)-specific CD8
T-cell responses and viral load has not been defined. In this study, we used a panel of major
histocompatibility complex class I tetramers to examine responses to frequently targeted
CD8 T-cell epitopes in a large cohort of antiretroviral-therapy-naïve HIV type 1 clade C
virus-infected persons in KwaZulu Natal, South Africa. In terms of effector functions of
proliferation, cytokine production, and degranulation, only proliferation showed a significant …
T-cell responses and viral load has not been defined. In this study, we used a panel of major
histocompatibility complex class I tetramers to examine responses to frequently targeted
CD8 T-cell epitopes in a large cohort of antiretroviral-therapy-naïve HIV type 1 clade C
virus-infected persons in KwaZulu Natal, South Africa. In terms of effector functions of
proliferation, cytokine production, and degranulation, only proliferation showed a significant …
Abstract
The relationship between the function of human immunodeficiency virus (HIV)-specific CD8 T-cell responses and viral load has not been defined. In this study, we used a panel of major histocompatibility complex class I tetramers to examine responses to frequently targeted CD8 T-cell epitopes in a large cohort of antiretroviral-therapy-naïve HIV type 1 clade C virus-infected persons in KwaZulu Natal, South Africa. In terms of effector functions of proliferation, cytokine production, and degranulation, only proliferation showed a significant correlation with viral load. This robust inverse relationship provides an important functional correlate of viral control relevant to both vaccine design and evaluation.
American Society for Microbiology