Aggregate‐prone proteins are cleared from the cytosol by autophagy: therapeutic implications
A Williams, L Jahreiss, S Sarkar, S Saiki… - Current topics in …, 2006 - Elsevier
Intracellular protein misfolding/aggregation are features of many late‐onset
neurodegenerative diseases, called proteinopathies. These include Alzheimer's disease,
Parkinson's disease, tauopathies, and polyglutamine expansion diseases [eg, Huntington's
disease; and various spinocerebellar ataxias (SCAs), like SCA3]. There are no effective
strategies to slow or prevent the neurodegeneration resulting from these diseases in
humans. The mutations causing many proteinopathies (eg, polyglutamine diseases and …
neurodegenerative diseases, called proteinopathies. These include Alzheimer's disease,
Parkinson's disease, tauopathies, and polyglutamine expansion diseases [eg, Huntington's
disease; and various spinocerebellar ataxias (SCAs), like SCA3]. There are no effective
strategies to slow or prevent the neurodegeneration resulting from these diseases in
humans. The mutations causing many proteinopathies (eg, polyglutamine diseases and …
