The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis
WK Kroeze, BL Roth - Biological psychiatry, 1998 - Elsevier
This review summarizes the molecular biology of serotonin (5-HT; 5-hydroxytryptamine)
receptors and indicates the potential relevance of this information for the treatment of mood
and psychotic disorders. At least 15 separate subtypes of 5-HT receptors have been
identified by molecular cloning techniques to be distinct genetic entities. Subtle differences
in the primary amino acid sequences of these receptors can yield large differences in ligand
selectivity. Additionally, it has recently been discovered that drugs such as atypical …
receptors and indicates the potential relevance of this information for the treatment of mood
and psychotic disorders. At least 15 separate subtypes of 5-HT receptors have been
identified by molecular cloning techniques to be distinct genetic entities. Subtle differences
in the primary amino acid sequences of these receptors can yield large differences in ligand
selectivity. Additionally, it has recently been discovered that drugs such as atypical …
