[PDF][PDF] Focus on nasopharyngeal carcinoma
A and B: Typical nasopharyngeal undifferentiated carcinoma (WHO type III). A: The
carcinoma cells exhibit prominent nucleoli and arrange in syncytial clusters. Dense
infiltration of lymphocytes and plasma cells is evident (hematoxylin and eosin stain [H&E],
400×). B: In situ hybridization (ISH) for EBV RNA (EBER) reveals distinct nuclear positivity,
indicative of latent infection in carcinoma cells (400×). C and D: Squamous cell carcinoma
(SCC, WHO type I) from endemic region. C: SCC with intercellular bridges and keratinization …
carcinoma cells exhibit prominent nucleoli and arrange in syncytial clusters. Dense
infiltration of lymphocytes and plasma cells is evident (hematoxylin and eosin stain [H&E],
400×). B: In situ hybridization (ISH) for EBV RNA (EBER) reveals distinct nuclear positivity,
indicative of latent infection in carcinoma cells (400×). C and D: Squamous cell carcinoma
(SCC, WHO type I) from endemic region. C: SCC with intercellular bridges and keratinization …
A and B: Typical nasopharyngeal undifferentiated carcinoma (WHO type III). A: The carcinoma cells exhibit prominent nucleoli and arrange in syncytial clusters. Dense infiltration of lymphocytes and plasma cells is evident (hematoxylin and eosin stain [H&E], 400×). B: In situ hybridization (ISH) for EBV RNA (EBER) reveals distinct nuclear positivity, indicative of latent infection in carcinoma cells (400×).
C and D: Squamous cell carcinoma (SCC, WHO type I) from endemic region. C: SCC with intercellular bridges and keratinization is seen (H&E, 400×). D: ISH-EBV is positive (400×). E and F: SCC (WHO type I) from nonendemic region. E: SCC with intercellular bridges, keratinization, and keratin pearl are noted (H&E, 400×). F: ISHEBV is negative (400×).
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