[HTML][HTML] Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo
I Theurl, A Schroll, M Nairz, M Seifert, M Theurl… - …, 2011 - ncbi.nlm.nih.gov
I Theurl, A Schroll, M Nairz, M Seifert, M Theurl, T Sonnweber, H Kulaksiz, G Weiss
Haematologica, 2011•ncbi.nlm.nih.govBackground Increased levels of hepcidin, the master regulator of iron homeostasis,
contribute to the diversion of iron underlying the anemia of chronic disease. Yet hepcidin
levels are low in anemia of chronic disease with concomitant true iron deficiency. Here we
clarify the different underlying pathways regulating hepcidin expression under these
conditions in vivo.
contribute to the diversion of iron underlying the anemia of chronic disease. Yet hepcidin
levels are low in anemia of chronic disease with concomitant true iron deficiency. Here we
clarify the different underlying pathways regulating hepcidin expression under these
conditions in vivo.
Abstract
Background
Increased levels of hepcidin, the master regulator of iron homeostasis, contribute to the diversion of iron underlying the anemia of chronic disease. Yet hepcidin levels are low in anemia of chronic disease with concomitant true iron deficiency. Here we clarify the different underlying pathways regulating hepcidin expression under these conditions in vivo.
ncbi.nlm.nih.gov
