[HTML][HTML] Prostaglandin F2α-induced expression of 20α-hydroxysteroid dehydrogenase involves the transcription factor NUR77
CO Stocco, L Zhong, Y Sugimoto, A Ichikawa… - Journal of Biological …, 2000 - ASBMB
Prostaglandin F 2 α (PGF 2 α) binding to its receptor on the rat corpus luteum triggers
various signal transduction pathways that lead to the activation of a steroidogenic enzyme,
20α-hydroxysteroid dehydrogenase (20α-HSD), which in turn catabolizes progesterone. The
molecular mechanism underlying PGF 2 α-induced 20α-HSD enzyme activity has not yet
been explored. In this report we show, using mice lacking PGF 2 α receptor and pregnant
rats, that PGF 2 α is responsible for the rapid and massive expression of the 20α-HSD gene …
various signal transduction pathways that lead to the activation of a steroidogenic enzyme,
20α-hydroxysteroid dehydrogenase (20α-HSD), which in turn catabolizes progesterone. The
molecular mechanism underlying PGF 2 α-induced 20α-HSD enzyme activity has not yet
been explored. In this report we show, using mice lacking PGF 2 α receptor and pregnant
rats, that PGF 2 α is responsible for the rapid and massive expression of the 20α-HSD gene …
