Neonatal and adult megakaryopoiesis
ZJ Liu, M Sola-Visner - Current opinion in hematology, 2011 - journals.lww.com
ZJ Liu, M Sola-Visner
Current opinion in hematology, 2011•journals.lww.comA better characterization of the molecular differences between fetal/neonatal and adult
megakaryocytes is critical to elucidating the pathogenesis of a group of disorders that
selectively affect fetal/neonatal megakaryocyte progenitors, including the thrombocytopenia-
absent radius (TAR) syndrome, Down syndrome-TMD or Down syndrome-AMKL, and the
delayed platelet engraftment following cord blood transplantation.
megakaryocytes is critical to elucidating the pathogenesis of a group of disorders that
selectively affect fetal/neonatal megakaryocyte progenitors, including the thrombocytopenia-
absent radius (TAR) syndrome, Down syndrome-TMD or Down syndrome-AMKL, and the
delayed platelet engraftment following cord blood transplantation.
Summary
A better characterization of the molecular differences between fetal/neonatal and adult megakaryocytes is critical to elucidating the pathogenesis of a group of disorders that selectively affect fetal/neonatal megakaryocyte progenitors, including the thrombocytopenia-absent radius (TAR) syndrome, Down syndrome-TMD or Down syndrome-AMKL, and the delayed platelet engraftment following cord blood transplantation.
Lippincott Williams & Wilkins