Clonal Hematologic Disorders in Down Syndrome A Review
H Avet-Loiseau, F Mechinaud… - Journal of pediatric …, 1995 - journals.lww.com
Purpose: Children with Down syndrome (DS) carry an elevated risk of developing clonal
hematologic disorders. In this review, we summarize reported data describing the incidence
of leukemia in children with DS and associated leukemic cell phenotypic and functional
features. Patients and Methods: Major leukemic subtypes, acute lymphoblastic leukemia
(ALL), acute nonlymphoblastic leukemia (ANLL), myelodysplastic syndromes (MDS), and
transient abnormal myelopoiesis (TAM) are evaluated in the context of patient age and …
hematologic disorders. In this review, we summarize reported data describing the incidence
of leukemia in children with DS and associated leukemic cell phenotypic and functional
features. Patients and Methods: Major leukemic subtypes, acute lymphoblastic leukemia
(ALL), acute nonlymphoblastic leukemia (ANLL), myelodysplastic syndromes (MDS), and
transient abnormal myelopoiesis (TAM) are evaluated in the context of patient age and …