Correction of age-associated deficiency in germinal center response by immunization with immune complexes
B Zheng, K Switzer, E Marinova, D Wansley, S Han - Clinical immunology, 2007 - Elsevier
In aging, both primary and secondary antibody responses are impaired. One of the most
notable changes in age-associated immune deficiency is the diminished germinal center
(GC) reaction. This impaired GC response reduces antibody affinity maturation, decreases
memory B cell development, and prevents the establishment of long-term antibody-forming
cells in the bone marrow. It is of great importance to explore novel strategy in improving GC
response in the elderly. In this study, the efficacy of immunization with immune complexes in …
notable changes in age-associated immune deficiency is the diminished germinal center
(GC) reaction. This impaired GC response reduces antibody affinity maturation, decreases
memory B cell development, and prevents the establishment of long-term antibody-forming
cells in the bone marrow. It is of great importance to explore novel strategy in improving GC
response in the elderly. In this study, the efficacy of immunization with immune complexes in …