Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate, and …
BJ Attardi, A Zeleznik, H Simhan, JP Chiao… - American journal of …, 2007 - Elsevier
OBJECTIVE: This study was undertaken to determine whether the reduction in premature
birth attributable to 17-alpha hydroxyprogesterone caproate occurs because of a greater
affinity for progesterone or glucocorticoid receptors or by enhanced stimulation of
progestogen responsive genes when compared with progesterone. STUDY DESIGN: We
performed competitive steroid hormone receptor binding assays using cytosols expressing
either recombinant human progesterone receptor-A or-B or rabbit uterine or thymic cytosols …
birth attributable to 17-alpha hydroxyprogesterone caproate occurs because of a greater
affinity for progesterone or glucocorticoid receptors or by enhanced stimulation of
progestogen responsive genes when compared with progesterone. STUDY DESIGN: We
performed competitive steroid hormone receptor binding assays using cytosols expressing
either recombinant human progesterone receptor-A or-B or rabbit uterine or thymic cytosols …
