Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms
SS Pierangeli, PP Chen, E Raschi… - … in thrombosis and …, 2008 - thieme-connect.com
Seminars in thrombosis and hemostasis, 2008•thieme-connect.com
Antiphospholipid antibodies (Abs) are associated with thrombosis and are a risk factor for
recurrent pregnancy loss and obstetric complications in patients with the antiphospholipid
syndrome. It is generally accepted that the major autoantigen for aPL Abs is β 2 glycoprotein
I, which mediates the binding of aPL Abs to target cells (ie, endothelial cells, monocytes,
platelets, trophoblasts, etc.) leading to thrombosis and fetal loss.
recurrent pregnancy loss and obstetric complications in patients with the antiphospholipid
syndrome. It is generally accepted that the major autoantigen for aPL Abs is β 2 glycoprotein
I, which mediates the binding of aPL Abs to target cells (ie, endothelial cells, monocytes,
platelets, trophoblasts, etc.) leading to thrombosis and fetal loss.
Abstract
Antiphospholipid antibodies (Abs) are associated with thrombosis and are a risk factor for recurrent pregnancy loss and obstetric complications in patients with the antiphospholipid syndrome. It is generally accepted that the major autoantigen for aPL Abs is β 2 glycoprotein I, which mediates the binding of aPL Abs to target cells (ie, endothelial cells, monocytes, platelets, trophoblasts, etc.) leading to thrombosis and fetal loss.
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