PAC1 (pituitary adenylate cyclase activating polypeptide type I receptor) is a G-protein-
coupled receptor that binds the strongly conserved neuropeptide PACAP (pituitary
adenylate cyclase activating polypeptide) with a thousandfold higher affinity than the related
peptide VIP (vasoactive intestinal peptide). PAC1 shows strong expression in brain areas
which have been implicated in the emotional control of behavior, such as the amygdala, the
hypothalamus, the locus coeruleus and the periaqueductal gray. To assess whether PAC1 …