[HTML][HTML] Molecular cloning of transferrin receptor 2: a new member of the transferrin receptor-like family
H Kawabata, R Yang, T Hirama, PT Vuong… - Journal of Biological …, 1999 - ASBMB
Transferrin receptor (TfR) plays a major role in cellular iron uptake through binding and
internalizing a carrier protein transferrin (Tf). We have cloned, sequenced, and mapped a
human gene homologous to TfR, termed TfR2. Two transcripts were expressed from this
gene: α (∼ 2.9 kilobase pairs), and β (∼ 2.5 kilobase pairs). The predicted amino acid
sequence revealed that the TfR2-α protein was a type II membrane protein and shared a
45% identity and 66% similarity in its extracellular domain with TfR. The TfR2-β protein …
internalizing a carrier protein transferrin (Tf). We have cloned, sequenced, and mapped a
human gene homologous to TfR, termed TfR2. Two transcripts were expressed from this
gene: α (∼ 2.9 kilobase pairs), and β (∼ 2.5 kilobase pairs). The predicted amino acid
sequence revealed that the TfR2-α protein was a type II membrane protein and shared a
45% identity and 66% similarity in its extracellular domain with TfR. The TfR2-β protein …
